Series Summary for DCD000340SR

Transcriptomic analyses of Myc-induced zebrafish liver cancer

Survey

10.1242/dmm.010462

GSE40745

To study the characteristics and mechanisms of Myc-induced zebrafish liver tumor, next-generation sequencing-based SAGE analyses were used to examine the transcriptomes of tumor and control samples. The results indicated that ribosome proteins were overwhelmingly up-regulated in the Myc-induced liver tumors. Cross-species analyses showed that the zebrafish Myc model correlated well with Myc transgenic mouse models for liver cancers. The Myc-induced zebrafish liver tumors also possessed molecular signatures highly similar to human hepatocellular carcinoma (HCC). Thus, our zebrafish model demonstrated the conserved role of Myc in promoting hepatocarcinogenesis in all vertebrate species.

True

mickael.dong

June 8, 2017, 5:59 a.m.

Sept. 27, 2017, 8:53 a.m.

Assays

small-RNA-seq

Biosample ID Series biosample_type biosample_lab genetic_background stage anatomical_term Hours Post Fertilization
DCD006947BS DCD000340SR tissue Gong Lab, National University of Singapore SING 90 Days-2 Years liver adult
Applied Assay ID Biosample Replicate Assay
DCD001931AA DCD013462BR small-RNA-seq_Gong_Lab_0003AS
Sequencing ID Technical Replicate Sequencing Lab Platform Instrument Paired End Strand Sequencing Date
DCD002278SQ DCD002289TR Gong Lab, National University of Singapore SOLiD AB SOLiD System ✔ unstranded 04/02/2013
DCD004749DT: FASTQ
Biosample ID Series biosample_type biosample_lab genetic_background stage anatomical_term Treatment Hours Post Fertilization
DCD006948BS DCD000340SR tissue Gong Lab, National University of Singapore SING 90 Days-2 Years liver — adult
Applied Assay ID Biosample Replicate Assay
DCD001932AA DCD013461BR small-RNA-seq_Gong_Lab_0003AS
Sequencing ID Technical Replicate Sequencing Lab Platform Instrument Paired End Strand Sequencing Date
DCD002279SQ DCD002290TR Gong Lab, National University of Singapore SOLiD AB SOLiD System ✔ unstranded 04/02/2013
DCD004750DT: FASTQ
Biosample ID Series biosample_type biosample_lab genetic_background stage anatomical_term Treatment Hours Post Fertilization Mutation Description
DCD006949BS DCD000340SR tissue Gong Lab, National University of Singapore SING 90 Days-2 Years liver Doxycycline adult —
Applied Assay ID Biosample Replicate Assay
DCD001933AA DCD013460BR small-RNA-seq_Gong_Lab_0003AS
Sequencing ID Technical Replicate Sequencing Lab Platform Instrument Paired End Strand Sequencing Date
DCD002280SQ DCD002291TR Gong Lab, National University of Singapore SOLiD AB SOLiD System ✔ unstranded 04/02/2013
DCD004751DT: FASTQ
Biosample ID Series biosample_type biosample_lab genetic_background stage Controlled By anatomical_term Treatment Hours Post Fertilization Mutation Description
DCD006950BS DCD000340SR tissue Gong Lab, National University of Singapore SING 90 Days-2 Years liver Doxycycline adult Tg(fabp10:TA TRE:Myc krt4:GFP)
Applied Assay ID Biosample Replicate Assay Controlled By
DCD001934AA DCD013459BR small-RNA-seq_Gong_Lab_0003AS
Sequencing ID Technical Replicate Sequencing Lab Platform Instrument Chemistry Version Paired End Strand Maximum Read Length Sequencing Date
DCD002281SQ DCD002292TR Gong Lab, National University of Singapore SOLiD AB SOLiD System — ✔ unstranded — 04/02/2013
DCD004752DT: FASTQ