Transcriptomic analyses of Myc-induced zebrafish liver cancer
Survey
10.1242/dmm.010462
GSE40745
To study the characteristics and mechanisms of Myc-induced zebrafish liver tumor, next-generation sequencing-based SAGE analyses were used to examine the transcriptomes of tumor and control samples. The results indicated that ribosome proteins were overwhelmingly up-regulated in the Myc-induced liver tumors. Cross-species analyses showed that the zebrafish Myc model correlated well with Myc transgenic mouse models for liver cancers. The Myc-induced zebrafish liver tumors also possessed molecular signatures highly similar to human hepatocellular carcinoma (HCC). Thus, our zebrafish model demonstrated the conserved role of Myc in promoting hepatocarcinogenesis in all vertebrate species.
True
mickael.dong
June 8, 2017, 5:59 a.m.
Sept. 27, 2017, 8:53 a.m.
| Biosample ID | Series | biosample_type | biosample_lab | genetic_background | stage | Hours Post Fertilization |
|---|---|---|---|---|---|---|
| DCD006947BS | DCD000340SR | tissue | Gong Lab, National University of Singapore | SING | 90 Days-2 Years | adult |
| Applied Assay ID | Biosample Replicate | Assay |
|---|---|---|
| DCD001931AA | DCD013462BR | small-RNA-seq_Gong_Lab_0003AS |
| Sequencing ID | Technical Replicate | Sequencing Lab | Platform | Instrument | Sequencing Date |
|---|---|---|---|---|---|
| DCD002278SQ | DCD002289TR | Gong Lab, National University of Singapore | SOLiD | AB SOLiD System | 04/02/2013 |
| Biosample ID | Series | biosample_type | biosample_lab | genetic_background | stage | Hours Post Fertilization |
|---|---|---|---|---|---|---|
| DCD006948BS | DCD000340SR | tissue | Gong Lab, National University of Singapore | SING | 90 Days-2 Years | adult |
| Applied Assay ID | Biosample Replicate | Assay |
|---|---|---|
| DCD001932AA | DCD013461BR | small-RNA-seq_Gong_Lab_0003AS |
| Sequencing ID | Technical Replicate | Sequencing Lab | Platform | Instrument | Sequencing Date |
|---|---|---|---|---|---|
| DCD002279SQ | DCD002290TR | Gong Lab, National University of Singapore | SOLiD | AB SOLiD System | 04/02/2013 |
| Biosample ID | Series | biosample_type | biosample_lab | genetic_background | stage | Hours Post Fertilization |
|---|---|---|---|---|---|---|
| DCD006949BS | DCD000340SR | tissue | Gong Lab, National University of Singapore | SING | 90 Days-2 Years | adult |
| Applied Assay ID | Biosample Replicate | Assay |
|---|---|---|
| DCD001933AA | DCD013460BR | small-RNA-seq_Gong_Lab_0003AS |
| Sequencing ID | Technical Replicate | Sequencing Lab | Platform | Instrument | Sequencing Date |
|---|---|---|---|---|---|
| DCD002280SQ | DCD002291TR | Gong Lab, National University of Singapore | SOLiD | AB SOLiD System | 04/02/2013 |
| Biosample ID | Series | biosample_type | biosample_lab | genetic_background | stage | Hours Post Fertilization |
|---|---|---|---|---|---|---|
| DCD006950BS | DCD000340SR | tissue | Gong Lab, National University of Singapore | SING | 90 Days-2 Years | adult |
| Applied Assay ID | Biosample Replicate | Assay |
|---|---|---|
| DCD001934AA | DCD013459BR | small-RNA-seq_Gong_Lab_0003AS |
| Sequencing ID | Technical Replicate | Sequencing Lab | Platform | Instrument | Sequencing Date |
|---|---|---|---|---|---|
| DCD002281SQ | DCD002292TR | Gong Lab, National University of Singapore | SOLiD | AB SOLiD System | 04/02/2013 |